Lab Members
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Joan S. Brugge Principal Investigator |
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Xiangkun Han Postdoctoral Fellow Publications Research Interests: |
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Suha Naffar abu Amara Postdoctoral Fellow Research Interests: Intratumor heterogeneity in ovarian cancers. |
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Warner Chen Postdoctoral Fellow Research Interests: Drug resistance in cancers. |
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Jonathan Coloff Postdoctoral Fellow Research Interests: |
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Isaac Harris Postdoctoral Fellow Research Interests: The role of antioxidants in tumor initiation, progression and drug resistance. |
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Claudia Iavarone Postdoctoral Fellow |
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Marcin Iwanicki Postdoctoral Fellow Research Interests: Role of mutant p53 in high grade ovarian cancers. |
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Hendrik Johannes Kuiken Postdoctoral Fellow Publications Research Interests: Role of intratumor heterogeneity and the tumor micro-environment in tumor progression and drug response; Dynamics of (tumor) cell populations; Identification of tumor specific vulnerabilities |
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Carman Man-Chung Li Postdoctoral Fellow Publications Research interests: Breast cancer development and progression |
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Yaara Oren Postdoctoral Fellow Publications Research Interests: Breast cancer ecology and evolution |
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Jennifer M. Rosenbluth Postdoctoral Fellow Publications Research Title: BRCA1 loss of function in breast cancer |
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Ron Schackmann Postdoctoral Fellow Publications Research Interests: Investigate (BRCA-mutant) breast tissue heterogeneity by means of 'Cytometry by Time of Flight' (CyTOF/mass-cytometry).
- Develop an antibody panel compatible with breast cells.
- Run CyTOF samples on a Helios system (Fluidigm).
- Perform CyTOF analysis using model systems ranging from cell lines, human mammary epithelial cells (HMECs) and organoids to reductive human mammary tissue.
- Analyze high-dimensional CyTOF data using software such as viSNE (within cyt), X-Shift (within VorteX), SPADE, Citrus, Scaffold, ACCENSE and others.
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Daniel Stover Postdoctoral Fellow Research Interests: Role of intratumor heterogeneity in triple-negative breast cancer chemoresistance. |
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Nobuaki Takahashi Visiting Assistant Professor |
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Ioannis Zervantonakis Postdoctoral Fellow Publications PhD, Mechanical Engineering (in the laboratory of Prof. Roger Kamm), MIT 2013 Research interests:
- Tumor microenvironment: drug resistance heterogeneity - Microfluidic and microfabricated assays to model the tumor microenvironment (cell-cell interactions, hypoxia and biophysical signals: matrix stiffness, cellular contractility)
- Endothelial permeability regulation: role of immune cells, shear stress and hypoxia - Cell Migration and Intravasation: Role of cell-cell interactions |
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Jason Zoeller Instructor Research Interests: The influence of basement membrane and other extracellular matrix components on response to HER2-targeted breast cancer therapeutics |
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Jose Maria Amich Undergraduate Student Research Interest: Role of Antioxidants in Breast Cancers |
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Patricia Cho PhD student Research Interests: Role of antioxidants in Cancers |
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Jett Crowdis Undergraduate Student |
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Sabin Dhakal PhD Student Publications Research Interests: Intratumoral heterogeneity in breast cancer. |
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Kenneth Gray PhD Student Research: Cancer Heterogeneity |
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Natalie Hendrick PhD Student Publications Research Interests: Hippo-YAP signaling in breast cancer |
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Jennifer Endress Research Associate |
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Grace Gao Lab Manager |
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Ben Marks Research Associate Research Interests: Combination therapy for triple negative breast cancers |
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Laura Selfors Bioinformaticist |
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Aleksandr Vagodny Research Associate |