Dr. Joan Brugge’s laboratory investigates the mechanisms of cancer initiation, progression, and drug resistance. We study breast cancer, ovarian cancer, as well as other cancer types. We investigate different aspects of cancer biology, including tumor heterogeneity, cell-cell interactions, tumor microenvironment, cancer metabolism, drug resistance, and cell signaling. We utilizes a wide collection of tools, including 3D/organoid cell cultures, genetically-engineered and transplantation-based animal models, single-cell analysis, metabolomics, high-throughput microscopy, and other advanced technologies. Findings from her laboratory have provided important insights to the understanding and treatment of cancer.