Lab Members

Principal Investigator
Joan S. Brugge
Principal Investigator

Postdoctoral Fellows
Xiangkun Han
Postdoctoral Fellow

Publications

Research Interests: 

Suha Naffar abu Amara
Postdoctoral Fellow

Research Interests: Intratumor heterogeneity in ovarian cancers.

Warner Chen
Postdoctoral Fellow

Research Interests:  Drug resistance in cancers.

Jonathan Coloff
Postdoctoral Fellow

Research Interests: 

Isaac Harris
Postdoctoral Fellow

Research Interests:  The role of antioxidants in tumor initiation, progression and drug resistance.

Claudia Iavarone
Postdoctoral Fellow
Marcin Iwanicki
Postdoctoral Fellow

Research Interests: Role of mutant p53 in high grade ovarian cancers.

Hendrik Johannes Kuiken
Postdoctoral Fellow

Publications

Research Interests: Role of intratumor heterogeneity and the tumor micro-environment in tumor progression and drug response; Dynamics of (tumor) cell populations; Identification of tumor specific vulnerabilities

Carman Man-Chung Li
Postdoctoral Fellow

Publications

Research interests: Breast cancer development and progression

Yaara Oren
Postdoctoral Fellow

Publications

Research Interests: Breast cancer ecology and evolution

Jennifer M. Rosenbluth
Postdoctoral Fellow

Publications

Research Title:  BRCA1 loss of function in breast cancer

Ron Schackmann
Postdoctoral Fellow

Publications

Research Interests:

Investigate (BRCA-mutant) breast tissue heterogeneity by means of 'Cytometry by Time of Flight' (CyTOF/mass-cytometry).
- Develop an antibody panel compatible with breast cells.
- Run CyTOF samples on a Helios system (Fluidigm).
- Perform CyTOF analysis using model systems ranging from cell lines, human mammary epithelial cells (HMECs) and organoids to reductive human mammary tissue.
- Analyze high-dimensional CyTOF data using software such as viSNE (within cyt), X-Shift (within VorteX), SPADE, Citrus, Scaffold, ACCENSE and others.
Daniel Stover
Postdoctoral Fellow

Research Interests: Role of intratumor heterogeneity in triple-negative breast cancer chemoresistance.

Nobuaki Takahashi
Visiting Assistant Professor
Ioannis Zervantonakis
Postdoctoral Fellow

Publications

PhD, Mechanical Engineering (in the laboratory of Prof. Roger Kamm), MIT 2013


Research interests:
- Tumor microenvironment: drug resistance heterogeneity
- Microfluidic and microfabricated assays to model the tumor microenvironment (cell-cell interactions, hypoxia and biophysical signals: matrix stiffness, cellular contractility)
- Endothelial permeability regulation: role of immune cells, shear stress and hypoxia
- Cell Migration and Intravasation: Role of cell-cell interactions
Jason Zoeller
Postdoctoral Fellow

Research Interests: The influence of basement membrane and other extracellular matrix components on response to HER2-targeted breast cancer therapeutics

Students
Jose Maria Amich
Undergraduate Student

Research Interest: Role of Antioxidants in Breast Cancers

Patricia Cho
PhD student

Research Interests: Role of antioxidants in Cancers

Jett Crowdis
Undergraduate Student
Sabin Dhakal
PhD Student

Publications

Research Interests: Intratumoral heterogeneity in breast cancer.

Kenneth Gray
PhD Student

Research: Cancer Heterogeneity

Natalie Hendrick
PhD Student

Publications

Research Interests:  Hippo-YAP signaling in breast cancer

Staff
Jennifer Endress
Research Associate
Grace Gao
Lab Manager
Ben Marks
Research Associate

Research Interests: Combination therapy for triple negative breast cancers

Laura Selfors
Bioinformaticist
Aleksandr Vagodny
Research Associate

Alumni

Hanna Yoko Irie Mount Sinai Hospital
Assistant Professor
E-mail: hanna.irie@mssm.edu
Website: http://www.mountsinai.org/profiles/hanna-yoko-irie-
John Albeck University of California, Davis
Assistant Professor
E-mail: jgalbeck@ucdavis.edu
Website: http://www.mcb.ucdavis.edu/faculty-labs/albeck/
Amy Bui
Jayanta Debnath UCSF
Associate Professor, UCSF Department of Pathology
E-mail: jayanta.debnath@ucsf.edu
Website: http://pathology.ucsf.edu/debnath/research.html
Lisa Gallegos Roche Tissue Diagnostics/Ventana Medical Systems, Inc., Tucson, Arizona
Senior Scientist (Technology & Applied Research Group)
E-mail: lisa.gallegos@roche.com
Website: http://www.ventana.com/
Kripa. S. Ganesh Weill Cornell Medical College
PhD Student
Carina Hage Roche
PhD Student
Rex Hung Brigham and Women's Hospital, Boston
Resident in Pathology
Kevin Janes University of Virginia
Associate Professor of Biomedical Engineering
E-mail: kjanes@virginia.edu
Website: http://bme.virginia.edu/janes/index.html
Steven Jay Isakoff MGH Cancer Center, Massachusetts General Hospital
Medical Oncologist, Breast Cancer Specialist
Website: http://www.dfhcc.harvard.edu/insider/member-detail/member/steven-j-isakoff-md-phd/
Cheuk Leung University of Minnesota
Assistant Professor of Pharmacology
E-mail: ctleung@umn.edu
Website: http://www.pharmacology.med.umn.edu/fac_leung.html
Marco Mazzone Chiesi Farmaceutici
Medical Scientific Manager
Cindy Miranti Van Andel Research Institute
Associate Professor
E-mail: cindy.miranti@vai.org
Website: http://mirantilab.vai.org/overview/
Ghassan Mouneimne The University of Arizona Medical Center
Assistant Professor
E-mail: gmouneimne@email.arizona.edu
Website: http://www.mouneimne.arizona.edu/page1.html
Taru Muranen Beth Israel Deaconess Medical Center
Assistant Professor
E-mail: tmuranen@bidmc.harvard.edu
Website: http://www.muranenlab.org
Senthil Muthuswamy Beth Israel Deaconess Medical Center
Director, Cell Biology Program, Cancer Center
E-mail: s.Muthuswamy@utoronto.ca
Website: http://muthuswamylab.org/
Michael Overholtzer Memorial Sloan Kettering Cancer Center
Assistant Professor
E-mail: overhom1@mskcc.org
Website: https://www.mskcc.org/research-areas/labs/michael-overholtzer
Mauricio Reginato Drexel University College of Medicine
Assistant Professor, Department of Biochemistry & Molecular Biology
Website: http://www.drexel.edu/medicine/Faculty/Profiles/Mauricio-Reginato/
Zachary Schafer Harper Cancer Institute, University of Notre Dame
Associate Professor, Biological Sciences
E-mail: zschafe1@nd.edu
Website: http://harpercancer.nd.edu/people/zachary-schafer/
Kaylene Simpson Peter MacCallum Cancer Centre
Associate Professor
Tony Yeung University of Toronto